Matrix metalloproteinases at a glance.

The matrix metalloproteinases (MMPs) are one of the major families of proteinases that play key roles in the responses of cells to their microenvironment. Most notably the MMPs have the combined capacity to degrade all the components of the extracellular matrix. Besides modulating tissue structure to facilitate remodeling, cell migration, etc. MMP activities can result in the generation of epitopes that act as cell effectors or the release of sequestered growth factors. Proteolysis of adhesion molecules, growth factors, cytokines, chemokines and receptors have all been documented (Sternlicht and Werb, 2001) and the potential effects on cell behaviour are multifarious.